Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability.
Michael T PattersonYingzheng XuHannah HillmanVictoria OsinskiPatricia R SchrankAinsley E KennedyFanta BarrowAlisha ZhuSamuel TollisonSia ShekharIngunn M StromnesIlaria TassiDick WuXavier S ReveloBryce A BinstadtJesse W WilliamsPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Trem2 agonism expands atherosclerotic plaque macrophages by promoting cell survival and proliferation but improves features of plaque stability by rewiring foamy macrophage function to enhance cholesterol efflux and collagen deposition.