Nontuberculous mycobacterial infections in a Brazilian pediatric population: a seven-year survey.
Renan Marrichi MauchAndrea A S MansinhoPriscilla M O RochaTânia R ZaccariottoCarlos Emílio LevyMarcos Tadeu Nolasco da SilvaPublished in: Pathogens and global health (2020)
The aim of this study was to describe the frequency of nontuberculous mycobacteria (NTM) isolation and their related outcomes among pediatric patients of a Brazilian university hospital from 2012 to 2019. NTM were identified in different clinical samples by microbiological culture and molecular-based methods. NTM were isolated from 14 patients, out of whom four (27%) were infected and were treated accordingly. Two were infected with Mycobacterium avium complex (MAC), two with M. abscessus complex (MABSC) and one with M. intracellulare. Two patients had cystic fibrosis-related lung disease and improved after successful NTM eradication. One patient was HIV-positive and died. One patient had severe combined immunodeficiency (SCID)-related pneumonia and is currently being followed-up. We conclude that NTM frequency in our center was low among pediatric patients. Whether this is inherent to Brazilian patients, due to the broad coverage of the Bacille Calmette-Guérin (BCG) vaccine in Brazil, or a result of underdiagnosis remains to be elucidated.
Keyphrases
- end stage renal disease
- cystic fibrosis
- ejection fraction
- chronic kidney disease
- hiv positive
- prognostic factors
- south africa
- intensive care unit
- case report
- pseudomonas aeruginosa
- early onset
- helicobacter pylori
- patient reported outcomes
- hepatitis c virus
- drug induced
- single molecule
- acute respiratory distress syndrome
- air pollution
- respiratory failure