Glycyrrhizin through liquorice intake modulates ACE2 and HMGB1 levels-A pilot study in healthy individuals with implications for COVID-19 and ARDS.

Felix BuderSimina-Ramona SelejanMathias HohlMichael KindermannChristian Herr Philipp M LepperRobert BalsBernd SalzbergerFelix MahfoudMichael Böhm

Published in: PloS one (2022)

Liquorice intake modulates ACE2 and HMGB1 levels in healthy individuals. HMGB1 is enhanced in mild COVID-19 and in ARDS with and without COVID-19, warranting evaluation of HMGB1 as a potential treatment target and glycyrrhizin, which is an active component of liquorice root extract, as a potential treatment in COVID-19 and non-COVID-19 respiratory disease.

Keyphrases

coronavirus disease
sars cov
respiratory syndrome coronavirus
acute respiratory distress syndrome
angiotensin ii
oxidative stress
mechanical ventilation
intensive care unit
physical activity
combination therapy
climate change