Analysis of β-catenin association with obesity in African Americans with premalignant and malignant colorectal lesions.
Babak ShokraniHassan BrimTahmineh HydariAli AfsariEdward LeeMehdi NouraieZaki SherifHassan AshktorabPublished in: BMC gastroenterology (2020)
In our study, advanced adenoma and CRC were associated with activation of β-catenin in physically fit, overweight and obese patients. Thus, obesity and WNT/β-Catenin pathway seem to be independent in African American patients. WNT/β-Catenin signaling pathway has a potential to be used as an effector in colon carcinogenic transformation. Whether or not BMI is a modifier of this pathway needs to be investigated further.
Keyphrases
- weight loss
- obese patients
- african american
- cell proliferation
- weight gain
- bariatric surgery
- insulin resistance
- metabolic syndrome
- stem cells
- roux en y gastric bypass
- type diabetes
- epithelial mesenchymal transition
- gastric bypass
- end stage renal disease
- newly diagnosed
- ejection fraction
- body mass index
- prognostic factors
- physical activity
- dendritic cells
- regulatory t cells
- skeletal muscle
- patient reported outcomes
- immune response
- signaling pathway
- climate change
- atomic force microscopy
- risk assessment
- human health
- patient reported