Hypoxic preconditioning enhances the differentiation of bone marrow stromal cells into mature oligodendrocytes via the mTOR/HIF-1α/VEGF pathway in traumatic brain injury.
Xiaoyu YuanQianqian LuoLihua ShenJin ChenDeqiang GanYechao SunLingzhi DingGuo-Hua WangPublished in: Brain and behavior (2020)
The results provided mechanistic evidences suggesting that HP-treated BMSCs promoted remyelination partly by modulating the pro-survival mTOR/HIF-1α/VEGF signaling pathway.
Keyphrases
- endothelial cells
- signaling pathway
- traumatic brain injury
- bone marrow
- vascular endothelial growth factor
- cell proliferation
- pi k akt
- mesenchymal stem cells
- epithelial mesenchymal transition
- ischemia reperfusion injury
- induced apoptosis
- free survival
- anti inflammatory
- cerebral ischemia
- severe traumatic brain injury
- newly diagnosed
- brain injury