Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease.

Benjamin HuynhYuhong FuDeniz KirikJames M ShineGlenda M Halliday

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

These findings show that in the same Parkinson's disease cases cell loss in these neurotransmitter systems does not follow a strict caudal to rostral trajectory and suggests symptom onset may relate to substantial pathology in the noradrenergic A6 locus coeruleus neurons in people with reduced dopamine-producing A9 substantia nigra neurons. © 2021 International Parkinson and Movement Disorder Society.

Keyphrases

spinal cord
single cell
genome wide association study
mesenchymal stem cells
patient reported