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Comparison of Locus Coeruleus Pathology with Nigral and Forebrain Pathology in Parkinson's Disease.

Benjamin HuynhYuhong FuDeniz KirikJames M ShineGlenda M Halliday
Published in: Movement disorders : official journal of the Movement Disorder Society (2021)
These findings show that in the same Parkinson's disease cases cell loss in these neurotransmitter systems does not follow a strict caudal to rostral trajectory and suggests symptom onset may relate to substantial pathology in the noradrenergic A6 locus coeruleus neurons in people with reduced dopamine-producing A9 substantia nigra neurons. © 2021 International Parkinson and Movement Disorder Society.
Keyphrases
  • spinal cord
  • single cell
  • genome wide association study
  • mesenchymal stem cells
  • patient reported