SHED aggregate exosomes shuttled miR-26a promote angiogenesis in pulp regeneration via TGF-β/SMAD2/3 signalling.

Meiling Wu Xuemei LiuZihan LiXiaoyao HuangHao GuoXiaohe GuoXiaoxue YangBei LiKun XuanYan Jin

Published in: Cell proliferation (2021)

In summary, these data reveal that SA-Exo shuttled miR-26a promotes angiogenesis via TGF-β/SMAD2/3 signalling contributing to SHED aggregate-based pulp tissue regeneration. These novel insights into SA-Exo may facilitate the development of new strategies for pulp regeneration.

Keyphrases

transforming growth factor
stem cells
wound healing
cell proliferation
long non coding rna
epithelial mesenchymal transition
endothelial cells
long noncoding rna
vascular endothelial growth factor
mesenchymal stem cells
electronic health record
genome wide
big data
machine learning
signaling pathway