Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2.

Enis KostallariPetra HirsovaAlena PrasnickaVikas K VermaUsman YaqoobNicha WongjarupongLewis Rowland Roberts Vijay H Shah

Published in: Hepatology (Baltimore, Md.) (2018)

PDGFRα is enriched in EVs derived from PDGF-BB-treated HSCs in an Src homology 2 domain tyrosine phosphatase 2-dependent manner and these PDGFRα-enriched EVs participate in development of liver fibrosis. (Hepatology 2018;68:333-348).

Keyphrases

liver fibrosis
growth factor
tyrosine kinase
high fat diet induced
vascular smooth muscle cells
metabolic syndrome
smooth muscle
skeletal muscle
newly diagnosed
protein kinase
wild type