Differentially expressed proteins identified by TMT proteomics analysis in children with verrucous epidermal naevi.
Tao YuanM-L CaiY-M ShengX DingT-T ShenW-R LiH HuangLiang BoXue-Jun ZhangQ-X ZhuPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2021)
According to TMT-based proteomics and Western blotting results, we identified eight noteworthy proteins, Involucrin, NDUFA4, Loricrin, Keratin type II cytoskeletal 6A, BRAF, Filaggrin, S100A7 and Desmocollin-3, that were upregulated in the lesions of VEN children and may be associated with the pathogenesis of VEN. Our findings provide new starting points for identifying precise pathogenic mechanisms or therapeutic targets for VEN.