Postictal serotonin levels are associated with peri-ictal apnea.

Arun MurugesanM R Sandhya RaniLaura VilellaNuria LacueyJohnson P HampsonCarl L FaingoldDaniel FriedmanOrrin DevinskyRup K SainjuStephan SchueleBeate Diehl Maromi NeiRonald M HarperLisa M BatemanGeorge RichersonSamden D Lhatoo

Published in: Neurology (2019)

The data suggest that significant seizure-related increases in serum 5-HT levels are associated with a lower incidence of seizure-related breathing dysfunction, and may reflect physiologic changes that confer a protective effect against deleterious phenomena leading to SUDEP. These results need to be confirmed with a larger sample size study.

Keyphrases

temporal lobe epilepsy
obstructive sleep apnea
risk factors
electronic health record
oxidative stress
positive airway pressure
artificial intelligence
drug induced
deep learning