Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations.

Maud MaillardRina NishiiWenjian YangKeito HoshitsukiDivyabharathi ChepyalaShawn H R LeeJenny Q NguyenMary V RellingKristine R CrewsMark LeggasMeenu SinghJoshua L Y SuangAllen E J YeohSima JehaHiroto InabaChing-Hon PuiSeth E KarolAmita TrehanPrateek BhatiaFederico G Antillon KlussmannDeepa BhojwaniCyrine E HaidarJun J Yang

Published in: Journal of the National Cancer Institute (2024)

We recommend more substantial dose reductions to individualize MP therapy and mitigate toxicity in TPMT/NUDT15 IM/IM patients.

Keyphrases

acute lymphoblastic leukemia
end stage renal disease
ejection fraction
oxidative stress
chronic kidney disease
young adults
prognostic factors
peritoneal dialysis
stem cells
patient reported outcomes
mesenchymal stem cells
bone marrow
patient reported