Estimating colocalization probability from limited summary statistics.

Emily A KingFengjiao DunbarJustin Wade DavisJacob F Degner

Published in: BMC bioinformatics (2021)

We find that colocalization analysis performed with full summary statistics can be closely approximated when only the summary statistics of the top SNP are available for one or both traits. When applied to the full GWAS Catalog and GTEx eQTL, we find that colocalized trait-gene pairs are enriched in tissues relevant to disease etiology and for matches to approved drug mechanisms. POEMColoc R package is available at https://github.com/AbbVie-ComputationalGenomics/POEMColoc .

Keyphrases

genome wide
dna methylation
copy number
gene expression
high density
adverse drug
genetic diversity