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Nanomaterials in Skin Regeneration and Rejuvenation.

Emanuela BelluSerenella MediciDonatella CoradduzzaSara CrucianiEvzen AmlerMargherita Maioli
Published in: International journal of molecular sciences (2021)
Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration.
Keyphrases
  • wound healing
  • drug delivery
  • soft tissue
  • stem cells
  • endothelial cells
  • healthcare
  • public health
  • mental health
  • emergency department
  • cancer therapy
  • risk assessment
  • platelet rich plasma
  • hyaluronic acid