Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response.
Noha GwiliStacey J JonesWaleed Al AmriIan M CarrSarah HarrisBrian V HoganWilliam E HughesBaek KimFiona E LanglandsRebecca A Millican-SlaterArindam PramanikJames L ThorneEldo T VergheseGeoff WellsMervat HamzaLayla YounisNevine M F El DeebThomas A HughesPublished in: British journal of cancer (2021)
This study is the first to define the molecular profile of BCSCs from a range of primary breast cancers. ITGA7 acts as a predictive marker for chemotherapy response, in accordance with its downregulation in BCSCs.