Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis.
Lukas MuriDenis GrandgirardMichelle BuriMichael PernyStephen L LeibPublished in: Journal of neuroinflammation (2018)
Combined adjuvant therapy with the non-bacteriolytic antibiotic daptomycin and the MMP inhibitor Trocade integrates the neuroprotective effects of both single adjuvants in experimental paediatric pneumococcal meningitis by reducing neuroinflammation and brain damage, thereby improving neurofunctional outcome. This strategy represents a promising therapeutic option to improve the outcome of paediatric patients suffering from pneumococcal meningitis.
Keyphrases
- brain injury
- cerebral ischemia
- subarachnoid hemorrhage
- intensive care unit
- emergency department
- end stage renal disease
- cerebrospinal fluid
- ejection fraction
- newly diagnosed
- chronic kidney disease
- traumatic brain injury
- oxidative stress
- prognostic factors
- patient reported outcomes
- blood brain barrier
- mouse model
- lipopolysaccharide induced
- working memory
- patient reported