Unbound Brain-to-Plasma Partition Coefficient, K p,uu,brain -a Game Changing Parameter for CNS Drug Discovery and Development.
Irena LoryanAndreas ReichelBo FengChristoffer BundgaardChristopher ShafferCory KalvassDallas BednarczykDenise MorrisonDominique LesuisseEdmund HoppeGeorg C TerstappenHolger FischerLi DiNicola ColcloughScott SummerfieldStephen T BuckleyTristan S MaurerMarkus FridénPublished in: Pharmaceutical research (2022)
assessment and its validation satisfactory for drug discovery and early development, areas of improvement and future research to better understand human brain pharmacokinetics/pharmacodynamics translation have been identified.