The protective effects of pericyte-derived microvesicles on vascular endothelial functions via CTGF delivery in sepsis.

Henan ZhouDanyang ZhengHongchen WangYue WuXiaoyong PengQinghui LiTao LiLiangming Liu

Published in: Cell communication and signaling : CCS (2021)

PMVs may delivery CTGF to VECs, and promote the proliferation and angiogenesis ability by activating the CTGF-ERK1/2-STAT3 axis, thereby protecting pulmonary vascular function in sepsis. The therapeutic effect of PMVs was highly related to CD44-mediated absorption. Video Abstract.

Keyphrases

signaling pathway
septic shock
endothelial cells
acute kidney injury
intensive care unit
cell proliferation
pulmonary hypertension
blood brain barrier
pi k akt
vascular endothelial growth factor
wound healing