The natural history of low-grade dysplasia in Barrett's esophagus and risk factors for progression.

Mohamed HusseinVinay SehgalSarmed SamiPaul BassettRami SweisDavid GrahamAndrea TeleseDanielle MorrisManuel Rodriguez-JustoMarnix JansenMarco NovelliMatthew BanksLaurence B LovatRehan Haidry

Published in: JGH open : an open access journal of gastroenterology and hepatology (2021)

Our data show variability in the diagnosis of low-grade dysplasia. The cumulative incidence of progression and time to progression varied across subgroups. Confirmed low-grade dysplasia had a shorter progression time compared with the downstaged group. Nodularity at index endoscopy and multifocal low-grade dysplasia were significant risk factors for progression. It is important to differentiate these high-risk subgroups so that decisions on surveillance/endotherapy can be personalized.

Keyphrases

low grade
high grade
public health
risk factors
electronic health record
big data
deep learning