Squamous cell carcinoma of the eyelid.
Yasuyoshi SatoShunji TakahashiTakashi ToshiyasuHideki TsujiNobuhiro HanaiAkihiro HommaPublished in: Japanese journal of clinical oncology (2023)
Eyelid squamous cell carcinoma is a major type of rare eyelid cancer, together with basal cell carcinoma and sebaceous gland carcinoma. It is a painless disease that progresses slowly and is often detected by the appearance of nodules or plaques. Risk factors include exposure to ultraviolet light, fair skin, radiation and human papillomavirus infection. The standard treatment is surgical removal, and in cases of orbital invasion, orbital content removal is required. If sentinel node biopsy reveals a high risk of lymph node metastasis, adjuvant radiotherapy may be considered. Local chemotherapy, such as imiquimod and 5-fluorouracil, may be used for eyelid squamous cell carcinoma in situ. When surgery or radiotherapy is not recommended for distant metastases or locally advanced disease, drug therapy is often according to head and neck squamous cell carcinoma in Japan. The treatment often requires a multidisciplinary team to ensure the preservation of function and cosmetic appearance.
Keyphrases
- locally advanced
- squamous cell carcinoma
- lymph node metastasis
- squamous cell
- papillary thyroid
- rectal cancer
- neoadjuvant chemotherapy
- early stage
- risk factors
- radiation therapy
- minimally invasive
- basal cell carcinoma
- radiation induced
- quality improvement
- stem cells
- emergency department
- ultrasound guided
- acute coronary syndrome
- coronary artery bypass
- mesenchymal stem cells
- cell migration
- wound healing
- adverse drug
- replacement therapy
- free survival