NF-κB Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II-Hypertensive Mice.
Mohammad Iqbal H BhuiyanCullen B YoungIsrat JahanMd Nabiul HasanSydney FischerNur Farah Meor AzlanMingjun LiuAnsuman ChattopadhyayHuachen HuangKristopher T KahleJinwei ZhangSamuel M PoloyacBradley J MolyneauxAdam C StraubXianming DengDelphine GomezDandan SunPublished in: Stroke (2022)
The ang II-induced stimulation of NF-κB transcriptional activity upregulates brain WNK-SPAK-NKCC1 cascade and contributes to worsened ischemic stroke outcomes, illustrating the brain WNK-SPAK-NKCC1 complex as a therapeutic target for stroke with comorbid hypertension.
Keyphrases
- atrial fibrillation
- blood pressure
- signaling pathway
- cerebral ischemia
- white matter
- lps induced
- resting state
- angiotensin ii
- oxidative stress
- pi k akt
- gene expression
- nuclear factor
- functional connectivity
- high glucose
- transcription factor
- multiple sclerosis
- subarachnoid hemorrhage
- blood brain barrier
- high fat diet induced
- brain injury
- drug induced
- immune response
- glycemic control
- weight loss