In this paper, we report a 10-year-old girl with a calcified pituitary adenoma. Laboratory examination showed the growth hormone (GH) to be more than 50ug/L, and pituitary prolactin (PRL) was 27.42 ng/mL. Non-contrast-enhanced computed tomography (CT) scans indicated a large sellar occupation with multiple nodules of calcification. Subsequently, the patient underwent a transcranial resection. Histopathologic evaluation confirmed the diagnosis of pituitary adenoma with multiple calcifications Conclusion: Since the management and prognosis of adenomas with calcification from other occupations of the pituitary gland differ significantly, it is important to differentiate between the two.