Environmental and sex-specific molecular signatures of glioma causation.

Elizabeth B ClausVincent L Cannataro Stephen G Gaffney Jeffrey P Townsend

Published in: Neuro-oncology (2021)

Cancer-causing mutations in glioma primarily originated as a consequence of endogenous rather than exogenous factors. Mutations in helical versus kinase domains of genes in the phosphoinositide 3-kinase (PI3K) pathway are differentially selected in males and females. Additionally, a rare environmental risk factor is suggested for some cases of glioma- particularly in males.

Keyphrases

genome wide
risk factors
papillary thyroid
protein kinase
tyrosine kinase
squamous cell carcinoma
gene expression
squamous cell
risk assessment
climate change
young adults
lymph node metastasis