Environmental and sex-specific molecular signatures of glioma causation.
Elizabeth B ClausVincent L CannataroStephen G GaffneyJeffrey P TownsendPublished in: Neuro-oncology (2021)
Cancer-causing mutations in glioma primarily originated as a consequence of endogenous rather than exogenous factors. Mutations in helical versus kinase domains of genes in the phosphoinositide 3-kinase (PI3K) pathway are differentially selected in males and females. Additionally, a rare environmental risk factor is suggested for some cases of glioma- particularly in males.