GET73 modulates lipopolysaccharide- and ethanol-induced increase in cytokine/chemokine levels in primary cultures of microglia of rat cerebral cortex.
Maria C TomasiniAntonella LocheRoberto CacciagliaLuca FerraroSarah BeggiatoPublished in: Pharmacological reports : PR (2024)
- The current results provide the first in vitro evidence of GET73 protective properties against EtOH-induced neuroinflammation. These data add more information on the complex and multifactorial profile of action of the compound, further supporting the significance of developing GET73 as a therapeutic tool for the treatment of individuals with alcohol use disorders.
Keyphrases
- high glucose
- diabetic rats
- inflammatory response
- oxidative stress
- lps induced
- traumatic brain injury
- drug induced
- subarachnoid hemorrhage
- lipopolysaccharide induced
- toll like receptor
- healthcare
- functional connectivity
- immune response
- machine learning
- spinal cord injury
- health information
- blood brain barrier
- social media
- combination therapy
- deep learning
- smoking cessation