Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin and juvenile hormone.

Jiangtian Chen Marcela Nouzova Fernando G Noriega Marc Tatar

Published in: bioRxiv : the preprint server for biology (2024)

aging. Gut NPF modulates Drosophila aging through the integration of nutrient sensing, insulin signaling and juvenile hormone. Given the role of incretin-mimetic drugs to treat diabetes and obesity, it may be time to consider how incretin analogs could impact human aging.

Keyphrases

type diabetes
glycemic control
endothelial cells
metabolic syndrome
insulin resistance
cardiovascular disease
white matter
multiple sclerosis
weight gain
blood brain barrier
induced pluripotent stem cells
cerebral ischemia