Albendazole induces immunotherapy response by facilitating ubiquitin-mediated PD-L1 degradation.

Lin ZhuXinwei KuangGuanxiong ZhangLong LiangDandan LiuBin HuZuozhong XieHui LiHong LiuMao YeXiang ChenJing Liu

Published in: Journal for immunotherapy of cancer (2022)

Our findings revealed a previously unappreciated role of ABZ in antitumor immunity by inducing ubiquitin-mediated PD-L1 protein degradation, identified predictors for assessing the therapeutic efficacy of anti-PD-1 therapy, and provided novel therapeutic possibility by combination treatment of ABZ and CD73 blockade in cancers.

Keyphrases

small molecule
single cell
bone marrow
nk cells
cell therapy
childhood cancer