ABCA6 affects the malignancy of Ewing sarcoma cells via cholesterol-guided inhibition of the IGF1R/AKT/MDM2 axis.

Michela PaselloAnna Maria GiudiceCamilla CristalliMaria Cristina ManaraCaterina MancarellaAlessandro ParraMassimo SerraGiovanna MagagnoliFlorencia Cidre-AranazThomas G P GrünewaldCarla BiniPier-Luigi LolliniAlessandra LonghiDavide Maria DonatiKatia Scotlandi

Published in: Cellular oncology (Dordrecht) (2022)

Our study reveals that ABCA6 acts as tumor suppressor in EWS cells via cholesterol-mediated inhibition of IGF1R/AKT/MDM2 signaling, which promotes the pro-apoptotic effects of doxorubicin and reduces cell migration. Our findings also support a role of ABCA6 as biomarker of EWS progression and sustains its assessment for a more rational use of statins as adjuvant drugs.

Keyphrases

induced apoptosis
cell migration
cell cycle arrest
signaling pathway
pi k akt
cell death
cell proliferation
cardiovascular disease
early stage
endoplasmic reticulum stress
anti inflammatory
cancer therapy
drug induced