A controlled inflammation and a regulatory immune system are associated with more favorable prognosis of progressive multifocal leukoencephalopathy.
Nobuo SanjoYurie NoseYukiko Shishido-HaraSaneyuki MizutaniYoshiki SekijimaHitoshi AizawaToru TanizawaTakanori YokotaPublished in: Journal of neurology (2018)
Viral loads in the cerebrospinal fluid, a controlled inflammatory response mediated by CD4- and CD8-positive T cells, and plasma cells are associated with PML prognosis. Our findings further indicate that regulatory plasma cells may regulate inflammatory T-cell activity via a PD-1/PD-L1 immuno-checkpoint pathway, thereby protecting the uninfected brain from excessive immune-mediated damage during an active JC virus infection.
Keyphrases
- induced apoptosis
- oxidative stress
- inflammatory response
- cell cycle arrest
- cerebrospinal fluid
- transcription factor
- dna damage
- multiple sclerosis
- hiv infected
- cell death
- weight gain
- signaling pathway
- cell proliferation
- lipopolysaccharide induced
- white matter
- resting state
- body mass index
- functional connectivity
- nk cells
- pi k akt
- lps induced
- cerebral ischemia