The A4 study: β-amyloid and cognition in 4432 cognitively unimpaired adults.
Philip S InselMichael C DonohueReisa SperlingOskar HanssonNiklas Mattsson-CarlgrenPublished in: Annals of clinical and translational neurology (2020)
Clinical trials for cognitively unimpaired β-amyloid-positive individuals will include a large number of individuals where mechanisms downstream from β-amyloid pathology are already activated. These findings have implications for primary and secondary prevention of Alzheimer's disease.