Bufadienolides from Venenum Bufonis Inhibit mTOR-Mediated Cyclin D1 and Retinoblastoma Protein Leading to Arrest of Cell Cycle in Cancer Cells.

Huamei ChangJuan LiYajun CaoTiantian LiuSuofang ShiWenxing Chen

Published in: Evidence-based complementary and alternative medicine : eCAM (2018)

Bufadienolides inhibit proliferation partially due to arresting cell cycle in G1 phase, which is mediated by inhibiting mTOR-cyclin D1/Rb signal pathway.

Keyphrases

cell cycle
cell proliferation
signaling pathway
protein protein
amino acid
small molecule