Harnessing the power of IFN for therapeutic approaches to COVID-19.

Elise G VioxSteven E BosingerDaniel C DouekGideon Schreiber Mirko Paiardini

Published in: Journal of virology (2024)

Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19, examine the effects of manipulating IFN on SARS-CoV-2 viral replication and pathogenesis, and highlight pre-clinical and clinical studies evaluating the therapeutic efficacy of IFN in limiting COVID-19 severity.

Keyphrases

sars cov
coronavirus disease
respiratory syndrome coronavirus
immune response
dendritic cells
induced apoptosis
oxidative stress
machine learning
early onset
cell proliferation
pi k akt