General analysis of breast cancer patients tested for BRCA mutations and evaluation of acute radiotherapy toxicity.
Sule Karabulut GulHuseyin TepetamBerrin Benli YavuzOzge Kandemir GurselAyse AltinokIrem YukselOmar AlomariBanu AtalarIlknur Bilkay GorkenPublished in: Northern clinics of Istanbul (2024)
Our study supports existing literature by identifying an association between the presence of BRCA mutations and young age, nodal status, grade, and lymphovascular invasion. Additionally, we found no significant difference in the occurrence of radiotherapy toxicity between BRCA-positive and BRCA-negative patients. These findings suggest that radiotherapy can be safely administered to BRCA-positive patients after breast-conserving surgery or mastectomy. Keywords for our study include breast cancer, BRCA mutation, radiotherapy, and side effects.
Keyphrases
- end stage renal disease
- early stage
- locally advanced
- breast cancer risk
- ejection fraction
- newly diagnosed
- chronic kidney disease
- radiation induced
- peritoneal dialysis
- systematic review
- neoadjuvant chemotherapy
- oxidative stress
- risk assessment
- squamous cell carcinoma
- lymph node
- liver failure
- intensive care unit
- lymph node metastasis
- patient reported outcomes
- hepatitis b virus
- patient reported
- coronary artery bypass
- percutaneous coronary intervention
- extracorporeal membrane oxygenation