Factor Xa Inhibition Reduces Coagulation Activity but Not Inflammation Among People With HIV: A Randomized Clinical Trial.

Jason V BakerJulian WolfsonTess PetersonMicah MooberryMatthew GisselHarry MystakelisMichael W HendersonKelly Garcia-MyersFrank S RhameTimothy W SchackerKathleen E Brummel-ZiedinsIrini SeretiNigel S KeyRussell P Tracy

Published in: Open forum infectious diseases (2020)

The direct factor Xa inhibitor edoxaban led to a substantial reduction in coagulation but no effect on inflammation or immune activation. These results do not support that hypercoagulation contributes to ongoing inflammation during chronic antiretroviral therapy-treated HIV disease.

Keyphrases

antiretroviral therapy
hiv infected
hiv positive
human immunodeficiency virus
oxidative stress
hiv aids
hiv infected patients
hiv testing
hepatitis c virus
men who have sex with men
venous thromboembolism
south africa
light emitting