Massive invasion of organellar DNA drives nuclear genome evolution in Toxoplasma .
Sivaranjani NamasivayamCheng SunAssiatu B BahJenna OberstallerEdwin Pierre-LouisRonald Drew EtheridgeCédric FeschotteEllen J PrithamJessica C KissingerPublished in: bioRxiv : the preprint server for biology (2023)
and closely-related species have the largest observed organellar genome fragment content (>11,000 insertion comprising over 1 Mb of DNA) inserted into their nuclear genome sequence despite their compact 65 Mb nuclear genome. Insertions are occurring at a rate that makes them a significant mutational force that deserves further investigation when examining causes of adaptation and virulence of these parasites.