Acute Phase Responses Vary Between Children of HbAS and HbAA Genotypes During Plasmodium falciparum Infection.
Mary TettehOtchere Addai-MensahZakaria SieduEmmanuel K BaafourHelena LampteyJovis WilliamsEdward KupehGodfred EgbiAnna Boadi KwayieGabriel AbbamDavid Amoah AfrifahAlexander Yaw DebrahMichael Fokuo OforiPublished in: Journal of inflammation research (2021)
Significant changes in APPs were found in HbAA children during malaria as compared to HbAS children, possibly due to differences in malaria-induced inflammation levels. This suggests that the HbAS genotype is associated with better control of P. falciparum infection-induced inflammatory response than HbAA genotype.