Integrating next-generation sequencing to endoscopic retrograde cholangiopancreatography (ERCP)-obtained biliary specimens improves the detection and management of patients with malignant bile duct strictures.

Aatur D SinghiMarina N NikiforovaJennifer ChennatGeorgios I PapachristouAsif KhalidMordechai RabinovitzRohit DasSavreet SarkariaM Samir AyassoAbigail I WaldSara E MonacoMichael NalesnikN Paul OhoriDavid GellerAllan TsungAmer H ZureikatHerbert ZehJ Wallis MarshMelissa HoggKenneth LeeDavid L BartlettJames F PingpankAbhinav HumarNathan BaharyAnil K DasyamRandall BrandKenneth E FasanellaKevin McGrathAdam Slivka

Published in: Gut (2019)

The combination of BiliSeq and pathological evaluation of biliary specimens increased the detection of malignant strictures, particularly in patients with PSC. Additionally, BiliSeq identified alterations that may stratify patients for specific anticancer therapies.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
loop mediated isothermal amplification
ultrasound guided
real time pcr
prognostic factors
fine needle aspiration
patient reported outcomes
circulating tumor
patient reported