Fracture Risk in Pediatric Patients With MEN2B.
Iris LiIris R HartleyJoanna Klubo-GwiedzdzinskaJames C ReynoldsBarbara J ThomasJulie HoganMahider M EnyewEva DombiAlexander LingSrivandana AkshintalaDavid J VenzonJaydira Del RiveroMichael CollinsJohn W GlodPublished in: The Journal of clinical endocrinology and metabolism (2022)
In this group of patients with MEN2B, there was an increased overall risk of fracture compared to general pediatric cohorts in the United States. Less common sites of fracture were also observed. This suggests a possible effect of an activating RET mutation on bone physiology and warrants further investigation.