Hypomethylation of SNCA in Idiopathic REM Sleep Behavior Disorder Associated With Phenoconversion.

Yuan LiShuwen HaoHui ZhangWei MaoJinhua XueYanli ZhangYanning CaiPiu Chan

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

Peripheral blood α-synuclein intron 1 was hypomethylated in idiopathic rapid eye movement sleep behavior disorder patients. α-Synuclein methylation levels may be useful biomarkers to screen patients, predict phenoconversion, and monitor disease progression. © 2020 International Parkinson and Movement Disorder Society.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
peripheral blood
newly diagnosed
prognostic factors
peritoneal dialysis
sleep quality
patient reported outcomes
depressive symptoms
high throughput
genome wide
patient reported
sensitive detection