Engineering Cell Surface Function with DNA Origami.
Ehsan AkbariMolly Y MollicaChristopher R LucasSarah M BushmanRandy A PattonMelika ShahhosseiniJonathan W SongCarlos E CastroPublished in: Advanced materials (Deerfield Beach, Fla.) (2017)
A specific and reversible method is reported to engineer cell-membrane function by embedding DNA-origami nanodevices onto the cell surface. Robust membrane functionalization across epithelial, mesenchymal, and nonadherent immune cells is achieved with DNA nanoplatforms that enable functions including the construction of higher-order DNA assemblies at the cell surface and programed cell-cell adhesion between homotypic and heterotypic cells via sequence-specific DNA hybridization. It is anticipated that integration of DNA-origami nanodevices can transform the cell membrane into an engineered material that can mimic, manipulate, and measure biophysical and biochemical function within the plasma membrane of living cells.