GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension.

Xuran ChuVahid KheirollahiArun LingampallyPrakash ChelladuraiChanil ValasarajanAna Ivonne Vazquez-ArmendarizStefan HadzicAli KhadimOleg PakStefano Rivetti Jochen Wilhelm Marek Bartkuhn Slaven Crnkovic Alena MoiseenkoMonika HeinerSimone KrautLeila SotoodehJanine KoepkeGuilherme ValenteClemens Ruppert Thomas Braun Christos Samakovlis Ioannis AlexopoulosMario LoosoCho-Ming ChaoSusanne Herold Horst-Walter Birk Grazyna KwapiszewskaXiaoying HuangJin-San Zhang Soni Savai Pullamsetti Norbert WeissmannXiaokun LiElie El Agha Saverio Bellusci

Published in: Circulation research (2024)

Our data highlight GLI1+ cells as an alternative cellular source of VSMCs in pulmonary hypertension and suggest that these cells and the associated signaling pathways represent an important therapeutic target for further studies.

Keyphrases

induced apoptosis
pulmonary hypertension
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
pulmonary artery
oxidative stress
pulmonary arterial hypertension
machine learning
cell death
coronary artery
electronic health record