Dual action of high estradiol doses on MNU-induced prostate neoplasms in a rodent model with high serum testosterone: Protective effect and emergence of unstable epithelial microenvironment.
Bianca F GonçalvesSilvana G P de CamposRejane M GóesWellerson R ScaranoSebastião Roberto TabogaPatricia S L VilamaiorPublished in: The Prostate (2017)
Estrogen was able to slow tumor growth, but the epithelium exhibited features distinct from a normal prostatic epithelium, and this unstable microenvironment could trigger lesion recurrence over time.