NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells.

Margarite D MatossianSteven ElliottT Van HoangHope E BurksMaryl K WrightMadlin S AlzoubiThomas YanTiffany ChangHenri WathieuGabrielle O WindsorAlifiani Bo HartonoSean LeeWilliam J ZuercherDavid H DrewryCarrow WellsNirav KapadiaAaron BuechleinFang FangKenneth P NephewBridgette M Collins-BurowMatthew E Burow

Published in: Breast cancer research and treatment (2021)

While NEK5 activity modulated cytoskeletal changes and cell motility, NEK5 activity affected cell seeding capabilities but not metastatic colonization or proliferation in vivo. Here we characterized NEK5 function in breast cancer systems and we implicate NEK5 in regulating specific steps of metastatic progression.

Keyphrases

small cell lung cancer
squamous cell carcinoma
single cell
breast cancer cells
cell therapy
bone marrow
signaling pathway
staphylococcus aureus
mesenchymal stem cells
cystic fibrosis
young adults