Disruption of Fuz in mouse embryos generates hypoplastic hindbrain development and reduced cranial nerve ganglia.
Carlo Donato CaiaffaYogeshwari S AmbekarManmohan SinghYing Linda LinBogdan WlodarczykSalavat R AglyamovGiuliano ScarcelliKirill V LarinRichard H FinnellPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2024)
This study reveals that hypoplastic hindbrain development, identified by abnormal rhombomere morphology and persistent loss of ventral neuroepithelial stiffness, precedes exencephaly in Fuz ablated murine mutants, indicating that the gene Fuz has a critical function sustaining normal neural tube development and neuronal differentiation.