Antigen Discovery for Next-Generation Pertussis Vaccines Using Immunoproteomics and Transposon-Directed Insertion Sequencing.
Kelsey A GreggYihui WangJason WarfelElizabeth SchoenfeldEwa JankowskaJohn F CipolloMatthew MayhoChristine BoinettDeepika PrasadTimothy J BrickmanSandra K ArmstrongJulian ParkhillRicardo Da Silva AntunesAlessandro SetteJames F PapinRoman WolfTod J MerkelPublished in: The Journal of infectious diseases (2023)
The B. pertussis antigens identified as immunogenic, essential for persistence in the airway, and membrane-localized warrant further investigation for inclusion in vaccines designed to reduce or prevent carriage of bacteria in the airway of vaccinated individuals.