Effects of bortezomib on mouse preimplantation embryo development in vitro.

Published in: Birth defects research (2021)

We indicated that bortezomib adversely affects preimplantation embryo development in a dose, time, and developmental stage dependent manner. Moreover, bortezomib treatment inhibits preimplantation embryo development and induces cytoplasmic fragmentation and cell-cycle arrest on embryos.

Keyphrases

multiple myeloma
cell cycle arrest
cell death
newly diagnosed
pregnancy outcomes
signaling pathway