Traumatic bleeding and mortality in mice are intensified by iron deficiency anemia and can be rescued with tranexamic acid.
Bilgimol Chumappumkal JosephTro SekayanNicca FalahRichard F W BarnesVeronica FloodJuan A De Pablo-MorenoAnnette von DrygalskiPublished in: Research and practice in thrombosis and haemostasis (2024)
These observations provide first and critical proof-of-principle evidence that anemia accelerates traumatic bleeding and increases mortality, which could be rescued by anemia correction (parenteral iron) or periprocedural TXA.