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BCI-215, a Dual-Specificity Phosphatase Inhibitor, Reduces UVB-Induced Pigmentation in Human Skin by Activating Mitogen-Activated Protein Kinase Pathways.

Jeong Hyeon LeeMyoung Eun ChoiHongchan AnJu Won MoonHye Jin YeoYoungsup SongSung Eun Chang
Published in: Molecules (Basel, Switzerland) (2022)
As BCI-215 potently inhibits UV-stimulated melanogenesis, small molecules of DUSP-related signaling modulators may provide therapeutic benefits against pigmentation disorders.
Keyphrases
  • protein kinase
  • high glucose
  • small molecule
  • diabetic rats
  • signaling pathway
  • drug induced
  • tyrosine kinase
  • oxidative stress
  • aqueous solution