Disrupted Circadian Rhythm of Epinephrine in Males With Youth-Onset Type 2 Diabetes.
Stephanie GiessnerMegan E RamakerKathryn BlewMatthew L CrawfordRussell P GrantJames R BainMichael MuehlbauerNina JainDaniel S HsiaSarah ArmstrongMichael FreemarkPinar Gumus BalikciogluPublished in: Journal of the Endocrine Society (2022)
Circadian rhythm in catecholamines is disrupted in youth-onset T2D, with a blunted overnight fall in urinary epinephrine in males. Conversely, fasting morning norepinephrine and dopamine levels were lower in obese females with or without T2D. Higher nocturnal catecholamines in males with T2D might associate with, or predispose to, hypertension and cardiovascular complications. Lower catecholamine excretion in females with obesity might serve an adaptive, protective role.
Keyphrases
- type diabetes
- insulin resistance
- blood pressure
- metabolic syndrome
- weight loss
- mental health
- heart rate
- atrial fibrillation
- physical activity
- young adults
- adipose tissue
- resting state
- glycemic control
- blood glucose
- cardiovascular disease
- obstructive sleep apnea
- uric acid
- functional connectivity
- bariatric surgery
- sleep apnea
- skeletal muscle
- body mass index
- depressive symptoms