The role of p21-activated kinase 4 in the progression of oral squamous cell carcinoma by targeting PI3K-AKT signaling pathway.

Lan ZhangShanfeng LinZeying ZhangCong YanFayu Liu

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)

This study demonstrates that the PAK4 regulates the biological behaviors of OSCC by PI3K-AKT signaling pathway, and these findings might provide a novel strategy for OSCC treatment.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
cell proliferation
induced apoptosis
epithelial mesenchymal transition
protein kinase
combination therapy
oxidative stress