Ameliorated cellular hallmarks of myotonic dystrophy in hybrid myotubes from patient and unaffected donor cells.

Renée H L RaaijmakersC Rosanne M AusemsMarieke WillemseSarah A CummingBaziel G M van EngelenDarren G MoncktonHans van BokhovenDerick G Wansink

Published in: Stem cell research & therapy (2024)

Fusion of only a limited number of unaffected myogenic precursors to DM1 myotubes already ameliorates cellular disease hallmarks, offering promise for the development of cell transplantation strategies to lower disease burden.

Keyphrases

induced apoptosis
cell therapy
single cell
cell cycle arrest
case report
stem cells
early onset
metabolic syndrome
oxidative stress
cell proliferation
bone marrow
cell death
glycemic control
duchenne muscular dystrophy
muscular dystrophy