Preclinical Efficacy of Cabazitaxel Loaded Poly(2-alkyl cyanoacrylate) Nanoparticle Variants.

Remya Valsala Kumari Abhilash D PandyaLina PrasmickaiteAudun KvalvaagAnne Grethe MyrannAndreas K O ÅslundMarianne Steinsvik KjosCristina Fontecha-CuencaHajira B HaroonAna Rita Salgado RibeiroJutta Horejs-HoeckS Moein MoghimiÝrr MørchTore Skotland Kirsten SandvigGunhild Mari MælandsmoTore Geir Iversen

Published in: International journal of nanomedicine (2024)

We report for the first time, comparative efficacy of PEBCA and PEHCA NP variants in triple negative breast cancer models and show that CBZ-loaded PEBCA NPs exhibit a combined effect on tumor cells and on the tumor associated myeloid compartment, which may boost the anti-tumor response.

Keyphrases

drug delivery
copy number
cancer therapy
bone marrow
wound healing
acute myeloid leukemia
dendritic cells
ionic liquid
immune response
cell therapy
mesenchymal stem cells